{"topic_id":"companion_breed_health_american_cocker_spaniel_omia3629_dog","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_american_cocker_spaniel_omia3629_dog\ncategory: companion-breed-health\ntitle: \"American Cocker Spaniel — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/american_cocker_spaniel_omia3629_3629.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 140\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_american_cocker_spaniel_omia3629_dog/01_companion_breed_health_american_cocker_spaniel_omia3629_dog.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"American Cocker Spaniel — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA001871/9615/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# American Cocker Spaniel — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: American Cocker Spaniel (Dog)`\n- `Disorder: `\n- `Mode of inheritance: Autosomal recessive`\n- `Summary: This disorder in Dandie Dinmont Terriers was first described by Ahonen et al. (2013). Several studies investigated the condition in Basset Hounds (Ahram et al.,2014, 2015; Oliver et al., 2019). Park et al. (2022) reported that the American Cocker Spaniel (ACS) is among the most common breeds observed with PACG [primary angle closure glaucoma] development in dogs.`\n- `Defect: yes`\n## Associated gene(s)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- Gene: Entrez Gene ID 388244698 (no symbol in OMIA GeneSynonym) — OMIA Phene_Gene\n- OMIA molecular-genetics note: Ahram et al. (2015) reported a potentially pathogenic missense mutation in the nebulin gene (NEB) (g.5588214 A->G in exon 48; p.2051 Lys->Arg), which is located in their candidate region of CFA19q, as being strongly (but not completely) associated with the disorder in Basset Hounds.\n\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2013. Genome-wide association study identifies a novel canine glaucoma locus. PLoS One — PubMed:PMID23951034 | DOI:10.1371/journal.pone.0070903 — OMIA Phene_Article / Article\n- 2015. Progression of pectinate ligament dysplasia over time in two populations of Flat-Coated Retrievers. Vet Ophthalmol — PubMed:PMID24025050 | DOI:10.1111/vop.12098 — OMIA Phene_Article / Article\n- 2015. Variants in nebulin (NEB) are linked to the development of familial primary angle closure glaucoma in Basset Hounds. PLoS One — PubMed:PMID25938837 | DOI:10.1371/journal.pone.0126660 — OMIA Phene_Article / Article\n- 2014. Identification of genetic loci associated with primary angle-closure glaucoma in the basset hound. Mol Vis — PubMed:PMID24791135 — OMIA Phene_Article / Article\n- 2015. Genetics of canine primary glaucomas. Vet Clin North Am Small Anim Pract — PubMed:PMID26277300 | DOI:10.1016/j.cvsm.2015.06.003 — OMIA Phene_Article / Article\n- 2015. Definition, classification, and pathophysiology of canine glaucoma. Vet Clin North Am Small Anim Pract — PubMed:PMID26456751 | DOI:10.1016/j.cvsm.2015.06.002 — OMIA Phene_Article / Article\n- 2017. Genetic and biochemical biomarkers in canine glaucoma. Vet Pathol — PubMed:PMID27681326 | DOI:10.1177/0300985816666611 — OMIA Phene_Article / Article\n- 2019. Primary closed angle glaucoma in the Basset Hound: Genetic investigations using genome-wide association and RNA sequencing strategies. Mol Vis — PubMed:PMID30820145 — OMIA Phene_Article / Article\n- 2021. Proteomic analysis of aqueous humor in canine primary angle-closure glaucoma in American Cocker Spaniel dogs. Vet Ophthalmol — PubMed:PMID34558166 | DOI:10.1111/vop.12937 — OMIA Phene_Article / Article\n- 2021. Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma. Am J Vet Res — PubMed:PMID34936570 | DOI:10.2460/ajvr.21.04.0062 — OMIA Phene_Article / Article\n- 2022. Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility. Sci Rep — PubMed:PMID36348026 | DOI:10.1038/s41598-022-23238-1 — OMIA Phene_Article / Article\n- 2015. Ocular Disorders Presumed to be Inherited in Purebred Dogs (“The Blue Book”), 8th edition — OMIA Phene_Article / Article\n- (4 additional references in OMIA)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — American Cocker Spaniel — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"American Cocker Spaniel — Glaucoma, primary closed-angle (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/23951034/","retrieved":"","ref":"PMID 23951034","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":923,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}