{"topic_id":"companion_breed_health_abyssinian_omia3282_cat","category":"companion-breed-health","context":"---\nlicense: permission_granted\ntopic_id: companion_breed_health_abyssinian_omia3282_cat\ncategory: companion-breed-health\ntitle: \"Abyssinian — Nephrotic syndrome (hereditary; OMIA-verified breed predisposition)\"\nlang: en\nsource: \"OMIA (Online Mendelian Inheritance in Animals, University of Sydney) breed-specific hereditary-disorder record, saved verbatim to source_file; C1 substring-verified. Pulled 2026-08-02 from local OMIA database dump.\"\nsource_file: pdf-raw/breed-health/abyssinian_omia3282_3282.txt\ndate_parsed: 2026-08-02\ntokens_estimated: 262\nverification:\n  method: substring_match\n  claims: 6\n  passed: 6\n  date: 2026-08-02\nrecovered: false\npath: companion-breed-health/companion_breed_health_abyssinian_omia3282_cat/01_companion_breed_health_abyssinian_omia3282_cat.md\nsource_document: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\ncitation:\n  authority: \"OMIA — Online Mendelian Inheritance in Animals (University of Sydney)\"\n  title: \"Abyssinian — Nephrotic syndrome (hereditary; OMIA-verified breed predisposition)\"\n  url: \"https://omia.org/OMIA000712/9685/\"\n  retrieved: \"2026-08-02\"\n  ref: \"OMIA breed-specific hereditary-disorder records (omia.org), derived from local OMIA database dump; dataset: https://doi.org/10.25910/2AMR-PV70\"\n  doc_type: \"academic animal-genetics database (breed-specific disorder entries)\"\n  needs_review: false\n\n\n# Abyssinian — Nephrotic syndrome (hereditary; OMIA-verified breed predisposition)\n\nSource: first-hand OMIA (University of Sydney) breed-specific hereditary-disorder record, saved verbatim to `source_file`; every claim below is a C1 byte-substring of it.\n\n## Claims\n\n- `Breed: Abyssinian (Cat)`\n- `Disorder: `\n- `Mode of inheritance: White et al., (2008) describe eight cases of glomerular disease in young, related Abyssinian cats and propose a possible recessive mode of inheritance in these cats.`\n- `Summary: Nephrotic syndrome is often the consequence of underlying glomerular disease (White et al., 2008). See also: 'OMIA 000413-9685 : Glomerulonephritis in Felis catus' and 'OMIA 000040-9685 : Amyloidosis, renal in Felis catus' (Compiled by Rachel Natsume 13/9/2021)`\n- `Clin feat: Presentation with proteinuria, hypoproteinemia (hypoalbuminemia), hypercholesteremia, edema and/or effusion. Although peripheral subcutaneous edema is uncommon in cats, it may be present with severe hypoproteinemia (Farrow and Huxtable, 1971). Pleural effusion and ascites have been reported (White et al., 2008). Persistent proteinuria will exacerbate glomerular damage and may lead to renal failure (Kamie et al., 2010). (Compiled by Rachel Natsume 13/9/2021)`\n- `Defect: yes`\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2011. Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome.. J Vet Med Sci — PubMed:PMID20823662 | DOI:10.1292/jvms.10-0227 — OMIA Phene_Article / Article\n- 1981. Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat.. Vet Hum Toxicol — PubMed:PMID7257162 — OMIA Phene_Article / Article\n- 1971. Membranous nephropathy and the nephrotic syndrome in the cat.. J Comp Pathol — PubMed:PMID5167495 | DOI:10.1016/0021-9975(71)90073-9 — OMIA Phene_Article / Article\n- 1969. Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis.. Pathology — PubMed:PMID5408671 | DOI:10.3109/00313026909061038 — OMIA Phene_Article / Article\n- 1959. Prognosis in the nephrotic syndrome: a study with particular reference to the adult and older child.. Australas Ann Med — PubMed:PMID14407479 | DOI:10.1111/imj.1959.8.3.200 — OMIA Phene_Article / Article\n- 2008. Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats.. J Feline Med Surg — PubMed:PMID18455462 | DOI:10.1016/j.jfms.2007.11.007 — OMIA Phene_Article / Article\n- 1981. Membranous nephropathy in the cat and dog: a renal biopsy and follow-up study of sixteen cases.. Lab Invest — PubMed:PMID7024632 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:251300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:600995 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256370 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose.\n- 2011. Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome. J Vet Med Sci — PubMed:PMID20823662 | DOI:10.1292/jvms.10-0227 — OMIA Phene_Article / Article\n- 1981. Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat. Vet Hum Toxicol — PubMed:PMID7257162 — OMIA Phene_Article / Article\n- 1971. Membranous nephropathy and the nephrotic syndrome in the cat. J Comp Pathol — PubMed:PMID5167495 | DOI:10.1016/0021-9975(71)90073-9 — OMIA Phene_Article / Article\n- 1969. Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. Pathology — PubMed:PMID5408671 | DOI:10.3109/00313026909061038 — OMIA Phene_Article / Article\n- 1959. Prognosis in the nephrotic syndrome: a study with particular reference to the adult and older child. Australas Ann Med — PubMed:PMID14407479 | DOI:10.1111/imj.1959.8.3.200 — OMIA Phene_Article / Article\n- 2008. Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats. J Feline Med Surg — PubMed:PMID18455462 | DOI:10.1016/j.jfms.2007.11.007 — OMIA Phene_Article / Article\n- 1981. Membranous nephropathy in the cat and dog: a renal biopsy and follow-up study of sixteen cases. Lab Invest — PubMed:PMID7024632 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. Links this animal disorder to its human OMIM entry for comparative/translational context.\n- OMIM:251300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:600995 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256370 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2011. Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome. J Vet Med Sci — PubMed:PMID20823662 | DOI:10.1292/jvms.10-0227 — OMIA Phene_Article / Article\n- 1981. Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat. Vet Hum Toxicol — PubMed:PMID7257162 — OMIA Phene_Article / Article\n- 1971. Membranous nephropathy and the nephrotic syndrome in the cat. J Comp Pathol — PubMed:PMID5167495 | DOI:10.1016/0021-9975(71)90073-9 — OMIA Phene_Article / Article\n- 1969. Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. Pathology — PubMed:PMID5408671 | DOI:10.3109/00313026909061038 — OMIA Phene_Article / Article\n- 1959. Prognosis in the nephrotic syndrome: a study with particular reference to the adult and older child. Australas Ann Med — PubMed:PMID14407479 | DOI:10.1111/imj.1959.8.3.200 — OMIA Phene_Article / Article\n- 2008. Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats. J Feline Med Surg — PubMed:PMID18455462 | DOI:10.1016/j.jfms.2007.11.007 — OMIA Phene_Article / Article\n- 1981. Membranous nephropathy in the cat and dog: a renal biopsy and follow-up study of sixteen cases. Lab Invest — PubMed:PMID7024632 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:251300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:600995 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256370 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2011. Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome. J Vet Med Sci — PubMed:PMID20823662 | DOI:10.1292/jvms.10-0227 — OMIA Phene_Article / Article\n- 1981. Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat. Vet Hum Toxicol — PubMed:PMID7257162 — OMIA Phene_Article / Article\n- 1971. Membranous nephropathy and the nephrotic syndrome in the cat. J Comp Pathol — PubMed:PMID5167495 | DOI:10.1016/0021-9975(71)90073-9 — OMIA Phene_Article / Article\n- 1969. Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. Pathology — PubMed:PMID5408671 | DOI:10.3109/00313026909061038 — OMIA Phene_Article / Article\n- 1959. Prognosis in the nephrotic syndrome: a study with particular reference to the adult and older child. Australas Ann Med — PubMed:PMID14407479 | DOI:10.1111/imj.1959.8.3.200 — OMIA Phene_Article / Article\n- 2008. Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats. J Feline Med Surg — PubMed:PMID18455462 | DOI:10.1016/j.jfms.2007.11.007 — OMIA Phene_Article / Article\n- 1981. Membranous nephropathy in the cat and dog: a renal biopsy and follow-up study of sixteen cases. Lab Invest — PubMed:PMID7024632 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:251300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:600995 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256370 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n## Evidence (references)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- 2011. Progression of glomerulonephritis to end-stage kidney disease in a cat with nephrotic syndrome. J Vet Med Sci — PubMed:PMID20823662 | DOI:10.1292/jvms.10-0227 — OMIA Phene_Article / Article\n- 1981. Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat. Vet Hum Toxicol — PubMed:PMID7257162 — OMIA Phene_Article / Article\n- 1971. Membranous nephropathy and the nephrotic syndrome in the cat. J Comp Pathol — PubMed:PMID5167495 | DOI:10.1016/0021-9975(71)90073-9 — OMIA Phene_Article / Article\n- 1969. Nephrotic syndrome in the cat due to diffuse membranous glomerulonephritis. Pathology — PubMed:PMID5408671 | DOI:10.3109/00313026909061038 — OMIA Phene_Article / Article\n- 1959. Prognosis in the nephrotic syndrome: a study with particular reference to the adult and older child. Australas Ann Med — PubMed:PMID14407479 | DOI:10.1111/imj.1959.8.3.200 — OMIA Phene_Article / Article\n- 2008. Persistent haematuria and proteinuria due to glomerular disease in related Abyssinian cats. J Feline Med Surg — PubMed:PMID18455462 | DOI:10.1016/j.jfms.2007.11.007 — OMIA Phene_Article / Article\n- 1981. Membranous nephropathy in the cat and dog: a renal biopsy and follow-up study of sixteen cases. Lab Invest — PubMed:PMID7024632 — OMIA Phene_Article / Article\n\n## Comparative medicine (human OMIM)\nDerived from OMIA database dump (omia.xml, local); structured field, not verbatim prose. First-hand values below are verbatim substrings of the topic's pdf-raw/omia/<phene_id>.txt source file.\n- OMIM:251300 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256020 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:600995 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\n- OMIM:256370 (type: trait) — OMIA Group_OMIM (via OMIA_ID)\nverification_derived:\n  method: derived_from_dataset\n  source: \"OMIA database dump (omia.xml, local); fields Gene/Variant/Article/OMIM\"\n  note: \"Structured fields (gene, variant rsID/protein change, PubMed/DOI references, OMIM cross-link) extracted from OMIA dump and presented with first-hand values; not verbatim prose.\"\n","sources":["companion-breed-health — Abyssinian — Nephrotic syndrome (hereditary; OMIA-verified breed predisposition)"],"source":{"authority":"companion-breed-health","title":"Abyssinian — Nephrotic syndrome (hereditary; OMIA-verified breed predisposition)","url":"https://pubmed.ncbi.nlm.nih.gov/20823662/","retrieved":"","ref":"PMID 20823662","doc_type":"official source","source_document":"","verification_file":""},"source_document":"","source_file":"","trust":{"authority_tier":"ungraded","fidelity":"verbatim","license":null,"display_grade":"pending"},"tokens_estimated":2275,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}