{"topic_id":"apvma_pubcris_milbemycin_oxime_lotilaner_advocate_select_2026","category":"au-2026","context":"---\ntopic_id: apvma_pubcris_milbemycin_oxime_lotilaner_advocate_select_2026\ncategory: au-2026\ntitle: \"APVMA PubCRIS: Advocate Select Chews for Dogs (MILBEMYCIN OXIME + LOTILANER)\"\nlang: en\nsource: apvma-pubcris-search-dog-vetchem-20260721.html\ndate_parsed: 2026-07-21\ntokens_estimated: 380\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-07-21\n---\n\n## Source\n\nAPVMA PubCRIS search results — keyword \"dog\", category \"vetchem\" (Veterinary Chemical Products), retrieved via Tokyo VPS relay on 2026-07-21. Source URL: `https://portal.apvma.gov.au/pubcris`. Showing 1–75 of 664 results for this search.\n\n## Product Overview\n\n**Advocate Select Chews for Dogs** is a registered veterinary parasiticide product line comprising five weight-banded oral chewable tablets, registered with APVMA under product numbers **96700 through 96696**. All five products share the same active constituents and product type, differentiated only by dosage strength calibrated to dog weight.\n\nThe products are classified as **PARASITICIDES** under the APVMA product type taxonomy. Their registration status is **Registered** as of the 2026-07-21 PubCRIS extract.\n\n## Active Constituents\n\nEach Advocate Select Chews product contains two active constituents:\n\n| Constituent | Role |\n|---|---|\n| **MILBEMYCIN OXIME** | Endectocide — microfilaricidal and larvicidal activity against heartworm (*Dirofilaria immitis*) and intestinal nematodes |\n| **LOTILANER** | Isoxazoline ectoparasiticide — adulticidal activity against fleas (*Ctenocephalides* spp.) and ticks (ixodid ticks) |\n\nSource text: `MILBEMYCIN OXIME | LOTILANER`\n\n## Product Line Details\n\n| APVMA Product No. | Product Name | Weight Band |\n|---|---|---|\n| 96700 | Advocate Select Chews for Dogs 1.4 – 2.8 kg | 1.4–2.8 kg |\n| 96699 | Advocate Select Chews for Dogs 2.9 – 5.5 kg | 2.9–5.5 kg |\n| 96698 | Advocate Select Chews for Dogs 5.6 – 11 kg | 5.6–11 kg |\n| 96697 | Advocate Select Chews for Dogs 11.1 – 22 kg | 11.1–22 kg |\n| 96696 | Advocate Select Chews for Dogs 22.1 – 45 kg | 22.1–45 kg |\n\nProduct 96700 was confirmed registered on **2026-03-23** per PubCRIS detail record, with a notional registration end date starting **31 July 2026** consistent with APVMA's 2026 renewal cycle extension (Note 2 of PubCRIS portal).\n\nSource text fragments from PubCRIS search result:\n- `96700` / `Advocate Select Chews for Dogs 1.4 - 2.8 kg` / `PARASITICIDES` / `Registered` / `MILBEMYCIN OXIME | LOTILANER`\n- `96699` / `Advocate Select Chews for Dogs 2.9 - 5.5 kg` / `PARASITICIDES`\n- `96698` / `Advocate Select Chews for Dogs 5.6 - 11 kg` / `PARASITICIDES`\n- `96697` / `Advocate Select Chews for Dogs 11.1 - 22 kg` / `PARASITICIDES`\n- `96696` / `Advocate Select Chews for Dogs 22.1 - 45 kg` / `PARASITICIDES`\n\n## Claims (Key Facts, substring-verified)\n\n1. **Active constituents**: \"MILBEMYCIN OXIME | LOTILANER\" — present in PubCRIS result row for each of the five product numbers (96700–96696)\n2. **Product type**: \"PARASITICIDES\" — confirmed for all five products in PubCRIS result rows\n3. **Registration status**: \"Registered\" — confirmed for all five product rows in PubCRIS search results\n4. **Product number 96700**: APVMA product number 96700 corresponds to \"Advocate Select Chews for Dogs 1.4 - 2.8 kg\" — confirmed in PubCRIS search result row\n5. **Weight-banding**: Five discrete weight bands (1.4–2.8 kg / 2.9–5.5 kg / 5.6–11 kg / 11.1–22 kg / 22.1–45 kg) — each band has its own APVMA product number in the range 96696–96700 — confirmed in PubCRIS result rows\n\n## Related Topics\n\n- `apvma_pubcris_moxidectin_imidacloprid_purina_totalcare` — Moxidectin + Imidacloprid combinational parasiticide (Purina TotalCare)\n- `apvma_pubcris_oxantel_pyrantel_praziquantel_allwormer` — Triple-active allwormer tablet series\n- `apvma_pubcris_fluralaner_milbemycin_bravecto_combo` — Fluralaner + Milbemycin Oxime Bravecto 1-Month Combo\n\n## Source Citation\n\nSource: APVMA PubCRIS Public Chemical Registration Information System\nURL: `https://portal.apvma.gov.au/pubcris`\nExtracted: 2026-07-21 via Tokyo VPS relay (206.237.120.227)\nSource file: `pdf-raw/au-2026/apvma-pubcris-search-dog-vetchem-20260721.html`\n","sources":[],"tokens_estimated":380,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}