{"topic_id":"apvma_pubcris_maropitant_antiemetic_2026","category":"au-2026","context":"---\ntopic_id: apvma_pubcris_maropitant_antiemetic_2026\ncategory: au-2026\ntitle: \"APVMA PubCRIS: Maropitant Citrate for Dogs and Cats (NK1 Receptor Antagonist)\"\nlang: en\nsource: apvma-pubcris-search-dog-vetchem-20260721.html\ndate_parsed: 2026-07-21\ntokens_estimated: 360\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-07-21\n---\n\n## Source\n\nAPVMA PubCRIS search results — keyword \"dog\", category \"vetchem\", retrieved via Tokyo VPS relay on 2026-07-21. Source URL: `https://portal.apvma.gov.au/pubcris`.\n\n## Product Overview\n\n**Maropitant** is a registered veterinary pharmaceutical active constituent classified under the **CENTRAL NERVOUS SYSTEM** product type. It is a selective **neurokinin-1 (NK1) receptor antagonist** used as an antiemetic and antinauseant for dogs and cats. Maropitant is registered in Australia under two injectable formulations listed in PubCRIS:\n\n| APVMA Product No. | Product Name | Active Constituent | Status |\n|---|---|---|---|\n| 95854 | Maropitant 10 mg/mL Injection for Dogs and Cats | MAROPITANT AS MAROPITANT CITRATE | Registered |\n| 93514 | Vetemex 10 mg/mL Injection for Dogs and Cats | MAROPITANT AS MAROPITANT CITRATE | Registered |\n\nSource text from PubCRIS result rows:\n- `95854` / `Maropitant 10 mg/mL Injection for Dogs and Cats` / `CENTRAL NERVOUS SYSTEM` / `Registered` / `MAROPITANT AS MAROPITANT CITRATE`\n- `93514` / `Vetemex 10 mg/mL Injection for Dogs and Cats` / `CENTRAL NERVOUS SYSTEM` / `Registered` / `MAROPITANT AS MAROPITANT CITRATE`\n\n## Registered Date\n\nProduct 95854 was confirmed registered on **2025-11-07** per PubCRIS detail record, with a notional registration end date starting **31 July 2026** consistent with the APVMA 2026 renewal cycle extension policy (Note 2 of PubCRIS portal).\n\n## Active Constituent\n\n- **Maropitant as Maropitant Citrate**: 10 mg/mL concentration in the registered formulations. NK1 receptor antagonism blocks the action of substance P in the chemoreceptor trigger zone (CRTZ) and vomiting center, providing broad-spectrum antiemetic activity against central and peripheral emetogenic stimuli.\n\nSource text: `MAROPITANT AS MAROPITANT CITRATE`\n\n## Claims (Key Facts, substring-verified)\n\n1. **Active constituent**: \"MAROPITANT AS MAROPITANT CITRATE\" — confirmed in PubCRIS result rows for products 95854 and 93514\n2. **Product type**: \"CENTRAL NERVOUS SYSTEM\" — confirmed for both products in PubCRIS result rows\n3. **Registration status**: \"Registered\" — confirmed for both products\n4. **Concentration**: \"10 mg/mL\" — confirmed in product name fields for both products\n5. **Species**: \"for Dogs and Cats\" — confirmed in product name fields for both products\n\n## Related Topics\n\n- `apvma_pubcris_platform_overview_2026` — PubCRIS platform structure and active constituent expiry rules\n- `apvma_pubcris_analgesic_nsaid_meloxicam` — Meloxicam NSAID analgesic for dogs and cats\n\n## Source Citation\n\nSource: APVMA PubCRIS Public Chemical Registration Information System\nURL: `https://portal.apvma.gov.au/pubcris`\nExtracted: 2026-07-21 via Tokyo VPS relay (206.237.120.227)\nSource file: `pdf-raw/au-2026/apvma-pubcris-search-dog-vetchem-20260721.html`\n","sources":[],"tokens_estimated":360,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}