{"topic_id":"apvma_pubcris_fluralaner_milbemycin_bravecto_combo_2026","category":"au-2026","context":"---\ntopic_id: apvma_pubcris_fluralaner_milbemycin_bravecto_combo_2026\ncategory: au-2026\ntitle: \"APVMA PubCRIS: Bravecto 1-Month Combo (MILBEMYCIN OXIME + FLURALANER)\"\nlang: en\nsource: apvma-pubcris-search-dog-vetchem-20260721.html\ndate_parsed: 2026-07-21\ntokens_estimated: 360\nverification:\n  method: substring_match\n  claims: 5\n  passed: 5\n  date: 2026-07-21\n---\n\n## Source\n\nAPVMA PubCRIS search results — keyword \"dog\", category \"vetchem\", retrieved via Tokyo VPS relay on 2026-07-21. Source URL: `https://portal.apvma.gov.au/pubcris`.\n\n## Product Overview\n\n**BRAVECTO 1-MONTH COMBO** is a registered veterinary combination ectoparasiticide/endectocide product for dogs, registered for monthly administration. It provides simultaneous flea and tick control (via fluralaner) and heartworm/intestinal worm prevention (via milbemycin oxime). The 1-MONTH COMBO formulation is distinct from the standard Bravecto spot-on or oral products registered for 3- or 4-month intervals.\n\nThe product type is **PARASITICIDES**; registration status is **Registered**.\n\nSource text: `MILBEMYCIN OXIME | FLURALANER` (exact cell content from PubCRIS active constituent column)\n\n## Products Listed in PubCRIS\n\n| APVMA Product No. | Product Name | Active Constituents |\n|---|---|---|\n| 92606 | BRAVECTO 1-MONTH COMBO 400 MG FLURALANER PLUS 30 MG MILBEMYCIN OXIME CHEWABLE FOR LARGE DOGS | MILBEMYCIN OXIME \\| FLURALANER |\n| 92605 | BRAVECTO 1-MONTH COMBO 200 MG FLURALANER PLUS 15 MG MILBEMYCIN OXIME CHEWABLE FOR MEDIUM DOGS | MILBEMYCIN OXIME \\| FLURALANER |\n| 92604 | BRAVECTO 1-MONTH COMBO 100 MG FLURALANER PLUS 7.5 MG MILBEMYCIN OXIME CHEWABLE FOR SMALL DOGS | MILBEMYCIN OXIME \\| FLURALANER |\n\nSource text from PubCRIS result rows — verbatim cell content:\n- Cell 0: `92606` / Cell 1: `BRAVECTO 1-MONTH COMBO 400 MG FLURALANER PLUS 30 MG MILBEMYCIN OXIME CHEWABLE FOR LARGE DOGS` / Cell 2: `PARASITICIDES` / Cell 3: `Registered` / Cell 4: `MILBEMYCIN OXIME | FLURALANER`\n- Cell 0: `92605` / Cell 1: `BRAVECTO 1-MONTH COMBO 200 MG FLURALANER PLUS 15 MG MILBEMYCIN OXIME CHEWABLE FOR MEDIUM DOGS`\n- Cell 0: `92604` / Cell 1: `BRAVECTO 1-MONTH COMBO 100 MG FLURALANER PLUS 7.5 MG MILBEMYCIN OXIME CHEWABLE FOR SMALL DOGS`\n\n## Active Constituents\n\n- **MILBEMYCIN OXIME**: macrocyclic lactone — microfilaricidal and larvicidal action against *Dirofilaria immitis* (heartworm) and intestinal nematodes (*Ancylostoma*, *Toxocara*)\n- **FLURALANER**: isoxazoline compound — GABA-gated chloride channel antagonist; adulticidal activity against fleas (*Ctenocephalides felis*) and multiple tick species (*Ixodes*, *Rhipicephalus*, *Dermacentor*)\n\nSource text: `MILBEMYCIN OXIME | FLURALANER`\n\n## Claims (Key Facts, substring-verified)\n\n1. **Active constituents**: \"MILBEMYCIN OXIME | FLURALANER\" — confirmed verbatim in PubCRIS active constituent cell (cell 4) for product 92606. Note: order is reversed vs. the Advocate topic (where LOTILANER precedes MILBEMYCIN)\n2. **Product type**: \"PARASITICIDES\" — confirmed in product type column for all three products\n3. **Registration status**: \"Registered\" — confirmed in status column for all three products\n4. **Product number 92606**: APVMA product number 92606 confirmed in result row cell 0\n5. **1-MONTH COMBO product line**: \"BRAVECTO 1-MONTH COMBO\" — confirmed in product name for all three SKUs\n\n## Related Topics\n\n- `apvma_pubcris_milbemycin_oxime_lotilaner_advocate_select` — Milbemycin + Lotilaner Advocate product line\n- `apvma_pubcris_moxidectin_imidacloprid_purina_totalcare` — Moxidectin + Imidacloprid combination\n\n## Source Citation\n\nSource: APVMA PubCRIS Public Chemical Registration Information System\nURL: `https://portal.apvma.gov.au/pubcris`\nExtracted: 2026-07-21 via Tokyo VPS relay (206.237.120.227)\nSource file: `pdf-raw/au-2026/apvma-pubcris-search-dog-vetchem-20260721.html`\n","sources":[],"tokens_estimated":360,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}