{"topic_id":"ade_species_dog_top_drugs","category":"ade","context":"---\ntopic_id: ade_species_dog_top_drugs\ncategory: ade\ntitle: \"Top FDA ADE-report active ingredients by Dog reports\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-08-16 (species distribution per drug)\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json\ndate_parsed: 2026-08-16\ntokens_estimated: 300\nverification:\n  method: derived_from_dataset\n  claims: 20\n  note: \"Dog/Cat report counts per drug are taken verbatim (by value) from the cited openFDA JSON slice (ade_active_ingredients_2026-08-16_b1.json), which stores each drug's species-distribution aggregate. Counts are report-level, not additive, not causation.\"\n  date: 2026-08-16\nsource_document: \"FDA FAERS / openFDA Animal & Veterinary Event Reports\"\ncitation:\n  authority: \"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)\"\n  title: \"Top FDA ADE-report active ingredients by Dog reports\"\n  url: \"\"\n  retrieved: \"2026-08-16\"\n  ref: \"\"\n  doc_type: \"open dataset (JSON API)\"\n  needs_review: true\nauthority_tier: T1\nauthority_tier_basis: \"T1:fda\"\nauthority_tier_date: 2026-08-16\n---\n\n# Top FDA ADE-report active ingredients by Dog reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. The Dog report counts below are the Dog subset of each drug's overall ADE report total, taken from the 2026-08-16 openFDA species-distribution slice. Counts are report-level: one report may list multiple animals and reactions, so figures are not additive and do not imply causation. Ranking is by Dog report volume among the top active ingredients monitored.\n\n## Top drugs by Dog reports\n- potassium chloride: 248 Dog reports\n- human insulin: 1292 Dog reports\n- glycosaminoglycan polysulfate: 1432 Dog reports\n- fatty acids: 676 Dog reports\n- heartgard: 539 Dog reports\n- adequan: 417 Dog reports\n- mercaptobenzothiazole: 239 Dog reports\n- interceptor: 427 Dog reports\n- vetmedin: 419 Dog reports\n- hyaluronic acid: 193 Dog reports\n- same: 288 Dog reports\n- benadryl: 258 Dog reports\n- cosequin: 213 Dog reports\n- proin: 264 Dog reports\n- tris-edta: 219 Dog reports\n- bravecto: 214 Dog reports\n- nexgard: 226 Dog reports\n- lysine: 7 Dog reports\n- docp: 196 Dog reports\n- keppra: 180 Dog reports\n\n## Honest scope note\nReport counts reflect voluntary adverse-event reporting volume, not incidence or per-animal risk. Many of these drugs are companion-animal parasiticide or NSAID products whose Dog use dominates their reporting. Other species and reports with no species listed are excluded from the per-species figures. Source JSON: `pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json`.\n","sources":["US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database) — Top FDA ADE-report active ingredients by Dog reports (retrieved 2026-08-16)"],"source":{"authority":"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)","title":"Top FDA ADE-report active ingredients by Dog reports","url":"https://open.fda.gov/data/animal-and-veterinary/","retrieved":"2026-08-16","ref":"","doc_type":"open dataset (JSON API)","source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","verification_file":"pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json"},"source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","source_file":"pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json","trust":{"authority_tier":"T1","fidelity":"verbatim","license":null,"display_grade":"A"},"tokens_estimated":300,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}