{"topic_id":"ade_species_cat_top_drugs","category":"ade","context":"---\ntopic_id: ade_species_cat_top_drugs\ncategory: ade\ntitle: \"Top FDA ADE-report active ingredients by Cat reports\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-08-16 (species distribution per drug)\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json\ndate_parsed: 2026-08-16\ntokens_estimated: 300\nverification:\n  method: derived_from_dataset\n  claims: 20\n  note: \"Dog/Cat report counts per drug are taken verbatim (by value) from the cited openFDA JSON slice (ade_active_ingredients_2026-08-16_b1.json), which stores each drug's species-distribution aggregate. Counts are report-level, not additive, not causation.\"\n  date: 2026-08-16\nsource_document: \"FDA FAERS / openFDA Animal & Veterinary Event Reports\"\ncitation:\n  authority: \"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)\"\n  title: \"Top FDA ADE-report active ingredients by Cat reports\"\n  url: \"\"\n  retrieved: \"2026-08-16\"\n  ref: \"\"\n  doc_type: \"open dataset (JSON API)\"\n  needs_review: true\nauthority_tier: T1\nauthority_tier_basis: \"T1:fda\"\nauthority_tier_date: 2026-08-16\n---\n\n# Top FDA ADE-report active ingredients by Cat reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. The Cat report counts below are the Cat subset of each drug's overall ADE report total, taken from the 2026-08-16 openFDA species-distribution slice. Counts are report-level: one report may list multiple animals and reactions, so figures are not additive and do not imply causation. Ranking is by Cat report volume among the top active ingredients monitored.\n\n## Top drugs by Cat reports\n- potassium chloride: 128 Cat reports\n- human insulin: 1919 Cat reports\n- glycosaminoglycan polysulfate: 112 Cat reports\n- fatty acids: 41 Cat reports\n- heartgard: 0 Cat reports\n- adequan: 54 Cat reports\n- mercaptobenzothiazole: 24 Cat reports\n- interceptor: 0 Cat reports\n- vetmedin: 6 Cat reports\n- hyaluronic acid: 10 Cat reports\n- same: 11 Cat reports\n- benadryl: 23 Cat reports\n- cosequin: 56 Cat reports\n- proin: 2 Cat reports\n- tris-edta: 24 Cat reports\n- bravecto: 27 Cat reports\n- nexgard: 10 Cat reports\n- lysine: 208 Cat reports\n- docp: 1 Cat reports\n- keppra: 6 Cat reports\n\n## Honest scope note\nReport counts reflect voluntary adverse-event reporting volume, not incidence or per-animal risk. Many of these drugs are companion-animal parasiticide or NSAID products whose Cat use dominates their reporting. Other species and reports with no species listed are excluded from the per-species figures. Source JSON: `pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json`.\n","sources":["US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database) — Top FDA ADE-report active ingredients by Cat reports (retrieved 2026-08-16)"],"source":{"authority":"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)","title":"Top FDA ADE-report active ingredients by Cat reports","url":"https://open.fda.gov/data/animal-and-veterinary/","retrieved":"2026-08-16","ref":"","doc_type":"open dataset (JSON API)","source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","verification_file":"pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json"},"source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","source_file":"pdf-raw/ade/ade_active_ingredients_2026-08-16_b1.json","trust":{"authority_tier":"T1","fidelity":"verbatim","license":null,"display_grade":"A"},"tokens_estimated":300,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}