{"topic_id":"ade_milbemycin_lufenuron_by_species","category":"ade","context":"---\ntopic_id: ade_milbemycin_lufenuron_by_species\ncategory: ade\ntitle: \"FDA ADE reports for milbemycin, lufenuron (active ingredient) by species (Dog vs Cat) — totals, serious-AE share, top reactions\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-08-16\"\nsource_file: pdf-raw/ade/ade_species_slice_expand_2026-08-16.json\ndate_parsed: 2026-08-16\ntokens_estimated: 280\nverification:\n  method: derived_from_dataset\n  claims: 14\n  note: \"Values are report-level aggregates computed from the cited openFDA JSON source; not verbatim substrings. Counts are not additive (one report may list multiple reactions/animals). 'Serious' = FDA serious_ae flag. Species as filed in the report; Dog/Cat may not sum to the compound's overall total (other species and unlisted reports excluded).\"\n  date: 2026-08-16\nsource_document: \"FDA FAERS / openFDA Animal & Veterinary Event Reports\"\ncitation:\n  authority: \"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)\"\n  title: \"FDA ADE reports for milbemycin, lufenuron by species (Dog vs Cat)\"\n  url: \"\"\n  retrieved: \"2026-08-16\"\n  ref: \"\"\n  doc_type: \"open dataset (JSON API)\"\n  needs_review: true\nauthority_tier: T1\nauthority_tier_basis: \"T1:fda\"\nauthority_tier_date: 2026-08-16\n---\n\n# milbemycin, lufenuron — FDA Animal & Veterinary ADE Reports by Species (Dog vs Cat)\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-08-16. This topic covers adverse-event reports for the active ingredient **Milbemycin, Lufenuron** (queried as `drug.active_ingredients.name`). Overall report total for this ingredient: **15737**. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. \"Serious\" follows the FDA `serious_ae` flag. Species values are as filed in each report. The Dog and Cat figures below are subsets of this ingredient's overall report total and do not necessarily sum to it (other species and reports with no species listed are excluded).\n\n## Dog (14960 reports)\n- Serious adverse events (FDA `serious_ae` flag): 5333 (35.6% of 14960)\n- Top reported reactions (VEDDRA terms):\n  - INEFFECTIVE, HEARTWORM LARVAE 2794\n  - Lack of efficacy (endoparasite) - heartworm 2279\n  - Vomiting 2128\n  - Lack of efficacy (endoparasite) - hookworm 1819\n  - Diarrhoea 1012\n## Cat (16 reports)\n- Serious adverse events (FDA `serious_ae` flag): 0 (0.0% of 16)\n- Top reported reactions (VEDDRA terms):\n  - Accidental exposure 12\n  - Depression 6\n  - Ataxia 4\n  - Staggering 3\n  - Vomiting 3\n\n## Honest scope note\nThis topic is a species cross-section of FDA adverse-event reports for a single active ingredient, queried by `drug.active_ingredients.name`. Figures are aggregates of spontaneously reported adverse events and reflect reporting volume, not incidence or risk per animal treated. \"Lack of efficacy\" and similar terms denote product-performance reports, not adverse reactions. Different marketed presentations of the same compound (e.g. chewable vs spot-on) may be filed under distinct name strings in openFDA and are not merged here. Source JSON: `pdf-raw/ade/ade_species_slice_expand_2026-08-16.json` (openFDA animalandveterinary/event.json, pulled 2026-08-16).\n","sources":["US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database) — FDA ADE reports for milbemycin, lufenuron by species (Dog vs Cat) (retrieved 2026-08-16)"],"source":{"authority":"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)","title":"FDA ADE reports for milbemycin, lufenuron by species (Dog vs Cat)","url":"https://open.fda.gov/data/animal-and-veterinary/","retrieved":"2026-08-16","ref":"","doc_type":"open dataset (JSON API)","source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","verification_file":"pdf-raw/ade/ade_species_slice_expand_2026-08-16.json"},"source_document":"FDA FAERS / openFDA Animal & Veterinary Event Reports","source_file":"pdf-raw/ade/ade_species_slice_expand_2026-08-16.json","trust":{"authority_tier":"T1","fidelity":"verbatim","license":null,"display_grade":"A"},"tokens_estimated":280,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}