{"topic_id":"ade_ivermectin_adverse_events","category":"ade","context":"---\ntopic_id: ade_ivermectin_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for ivermectin (macrocyclic lactone (endectocide: heartworm/parasite)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 205\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-21\n---\n\n# ivermectin — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. ivermectin is a macrocyclic lactone (endectocide: heartworm/parasite).\n\n## Total reports\nivermectin: 194447\n\n## Reports by species (top entries)\n- Dog 167897\n- Horse 3499\n- Cattle 2458\n- Cat 1093\n- Human 739\n- Sheep 250\n\n## Top reported reactions (VEDDRA terms, top entries)\n- INEFFECTIVE, HEARTWORM LARVAE 37191\n- Lack of efficacy (endoparasite) - hookworm 26113\n- Lack of efficacy (endoparasite) - heartworm 24396\n- Vomiting 23145\n- Digestive tract disorder NOS 16792\n- INEFFECTIVE, ASCARIDS NOS 11897\n- Diarrhoea 10122\n- Cardiac disorder NOS 10105\n- Lack of efficacy - NOS 8927\n- Tablets, Abnormal 8038\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":205,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}