{"topic_id":"ade_doxycycline_adverse_events","category":"ade","context":"---\ntopic_id: ade_doxycycline\ncategory: ade\ntitle: \"FDA ADE reports for Doxycycline — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-21\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-21.json\ndate_parsed: 2026-07-21\ntokens_estimated: 200\nverification:\n  method: substring_match\n  claims: 15\n  passed: 15\n  date: 2026-07-21\n---\n\n# Doxycycline — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-21. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Doxycycline is a veterinary active ingredient.\n\n## Total reports\nDoxycycline: 4320\n\n## Reports by species (top entries)\n- Dog 3870\n- Cat 251\n- Horse 14\n- Human 7\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Lack of efficacy (endoparasite) - heartworm 1194\n- Vomiting 602\n- Lethargy (see also Central nervous system depression in 'Neurological') 468\n- Other abnormal test result NOS 357\n- Death by euthanasia 330\n- Anorexia 313\n- Elevated alanine aminotransferase (ALT) 284\n- Diarrhoea 269\n- Lack of efficacy - NOS 264\n- Death 241\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-21.json` (openFDA animalandveterinary/event.json, pulled 2026-07-21).\n","sources":[],"tokens_estimated":200,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}