{"topic_id":"ade_doramectin_adverse_events","category":"ade","context":"---\ntopic_id: ade_doramectin_adverse_events\ncategory: ade\ntitle: \"FDA ADE reports for Doramectin (macrocyclic lactone endectocide (parasite control)) — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-22\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json\ndate_parsed: 2026-07-22\ntokens_estimated: 198\nverification:\n  method: substring_match\n  claims: 34\n  passed: 34\n  date: 2026-07-22\n---\n\n# Doramectin — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Doramectin is a macrocyclic lactone endectocide (parasite control).\n\n## Total reports\nDoramectin: 4523\n\n## Reports by species (top entries)\n- Cattle 3085\n- Human 281\n- Pig 137\n- Dog 103\n- Cat 27\n- Goat 24\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Lack of efficacy (ectoparasite) - lice 1086\n- Pruritus 548\n- Death 457\n- Alopecia NOS 407\n- INEFFECTIVE, LICE BITING 372\n- Accidental exposure 292\n- Lack of efficacy (lice) 277\n- Caps, Abnormal 268\n- Unclassifiable adverse event 231\n- Vials, Leaking 199\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-22_b8.json` (openFDA animalandveterinary/event.json, pulled 2026-07-22).\n","sources":[],"tokens_estimated":271,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}