{"topic_id":"ade_cyclosporine_adverse_events","category":"ade","context":"---\ntopic_id: ade_cyclosporine\ncategory: ade\ntitle: \"FDA ADE reports for Cyclosporine — total reports, species & reaction breakdown\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-22\"\nsource_file: pdf-raw/ade/ade_active_ingredients_2026-07-22.json\ndate_parsed: 2026-07-22\ntokens_estimated: 200\nverification:\n  method: substring_match\n  claims: 16\n  passed: 16\n  date: 2026-07-22\n---\n\n# Cyclosporine — FDA Animal & Veterinary Adverse Event (ADE) Reports\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event report database. Data pulled 2026-07-22. Counts are report-level: one report may list multiple reactions and multiple animals, so figures are not additive and do not imply causation. Cyclosporine is a veterinary active ingredient.\n\n## Total reports\nCyclosporine: 21560\n\n## Reports by species (top entries)\n- Dog 15012\n- Cat 2987\n- Human 78\n-  2\n- Other 2\n\n## Top reported reactions (VEDDRA terms, top entries)\n- Vomiting 5175\n- Diarrhoea 2864\n- Anorexia 1468\n- Depression 1354\n- Pruritus 1160\n- Emesis 1077\n- Lethargy (see also Central nervous system depression in 'Neurological') 939\n- Other abnormal test result NOS 935\n- Weight loss 890\n- Elevated serum alkaline phosphatase (SAP) 734\n\n\"Lack of efficacy\" terms denote product-performance reports, not adverse reactions.\n\nSource JSON: `pdf-raw/ade/ade_active_ingredients_2026-07-22.json` (openFDA animalandveterinary/event.json, pulled 2026-07-22).\n","sources":[],"tokens_estimated":200,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}