{"topic_id":"ade_annual_trends_top_drugs","category":"ade","context":"---\ntopic_id: ade_annual_trends_top_drugs\ncategory: ade\ntitle: \"FDA ADE annual report trends by active ingredient (top antiparasitics, NSAIDs & article-referenced drugs) — 2026-07-30 snapshot\"\nlang: en\nsource: \"openFDA animalandveterinary/event.json (FDA CVM adverse event reports), pulled 2026-07-30\"\nsource_file: pdf-raw/ade/ade_timeseries_20260730.json\ndate_parsed: 2026-07-30\ntokens_estimated: 1200\nverification:\n  method: substring_match\n  claims: 0\n  passed: 0\n  date: 2026-07-30\nsource_document: \"FDA CVM Animal & Veterinary Event Reports (openFDA animalandveterinary/event.json)\"\ncitation:\n  authority: \"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)\"\n  title: \"FDA ADE annual report trends by active ingredient\"\n  url: \"https://api.fda.gov/animalandveterinary/event.json\"\n  retrieved: \"2026-07-30\"\n  ref: \"\"\n  doc_type: \"open dataset (JSON API)\"\n  needs_review: true\n---\n\n# FDA ADE annual report trends by active ingredient\n\nSource: openFDA `animalandveterinary/event.json`, the FDA Center for Veterinary Medicine (CVM) adverse event (ADE) report database. Data pulled 2026-07-30 (snapshot).\n\n**Caliber / how to read these numbers (snapshot-date + reported-not-causal):** Counts are report-level — one ADE report may list multiple reactions and multiple animals, so figures are not additive across drugs or across years, and do not imply causation. These are spontaneous reports submitted to FDA CVM; a reported association is not proof the drug caused the event. All annual figures below are aggregated from `original_receive_date` (the date FDA received the report), so 2026 is a partial year (data through the 2026-07-30 snapshot).\n\nEach line below is `drug total N; YYYY: count; ...` for the top-volume antiparasitic/NSAID active ingredients plus the drugs referenced in the drug-safety articles (gabapentin, sirolimus, bexagliflozin, dirlotapide, and the isoxazoline four: afoxolaner / fluralaner / sarolaner / lotilaner). Searches use the analyzed `drug.active_ingredients.name` field, so a name captures all formulations and brand variants.\n\nafoxolaner total 69037; 2013: 25; 2014: 3059; 2015: 5900; 2016: 7742; 2017: 7812; 2018: 5215; 2019: 5554; 2020: 5217; 2021: 4453; 2022: 3859; 2023: 4439; 2024: 7202; 2025: 7336; 2026: 1224\nbedinvetmab total 18921; 2023: 1313; 2024: 10012; 2025: 6663; 2026: 933\nbexagliflozin total 3835; 2023: 887; 2024: 1459; 2025: 1232; 2026: 257\ncarprofen total 52017; 1997: 1591; 1998: 3989; 1999: 3728; 2000: 4473; 2001: 2702; 2002: 1403; 2003: 887; 2004: 1292; 2005: 1958; 2006: 1952; 2007: 1825; 2008: 1756; 2009: 1597; 2010: 1441; 2011: 1344; 2012: 1703; 2013: 1575; 2014: 1475; 2015: 1571; 2016: 1534; 2017: 1346; 2018: 1165; 2019: 1025; 2020: 1004; 2021: 927; 2022: 929; 2023: 1144; 2024: 2190; 2025: 2129; 2026: 362\ndirlotapide total 2992; 2007: 380; 2008: 884; 2009: 986; 2010: 416; 2011: 191; 2012: 30; 2013: 90; 2014: 14; 2018: 1\nfluralaner total 88485; 2012: 1; 2014: 983; 2015: 5029; 2016: 7267; 2017: 9445; 2018: 9992; 2019: 9219; 2020: 8999; 2021: 7273; 2022: 6044; 2023: 6517; 2024: 7629; 2025: 8188; 2026: 1899\ngabapentin total 10444; 2011: 3; 2012: 63; 2013: 76; 2014: 42; 2015: 94; 2016: 164; 2017: 399; 2018: 437; 2019: 366; 2020: 500; 2021: 497; 2022: 601; 2023: 1223; 2024: 2907; 2025: 2607; 2026: 465\nimidacloprid total 29079; 2006: 3; 2007: 437; 2008: 632; 2009: 1071; 2010: 1365; 2011: 1553; 2012: 1924; 2013: 1953; 2014: 1823; 2015: 1678; 2016: 1654; 2017: 2192; 2018: 2078; 2019: 2033; 2020: 1840; 2021: 1637; 2022: 1408; 2023: 1395; 2024: 1340; 2025: 914; 2026: 149\nivermectin total 194443; 1987: 406; 1988: 396; 1989: 412; 1990: 177; 1991: 94; 1992: 41; 1993: 35; 1994: 69; 1995: 108; 1996: 159; 1997: 230; 1998: 147; 1999: 241; 2000: 169; 2001: 280; 2002: 702; 2003: 1306; 2004: 2556; 2005: 3325; 2006: 4378; 2007: 6085; 2008: 7269; 2009: 8386; 2010: 7945; 2011: 7599; 2012: 10423; 2013: 12034; 2014: 11196; 2015: 12135; 2016: 12019; 2017: 12386; 2018: 11711; 2019: 11930; 2020: 10340; 2021: 9501; 2022: 8055; 2023: 7228; 2024: 6475; 2025: 5519; 2026: 976\nlotilaner total 13432; 2015: 2; 2016: 1; 2017: 2; 2018: 574; 2019: 1304; 2020: 1811; 2021: 1449; 2022: 1321; 2023: 1469; 2024: 1587; 2025: 3158; 2026: 754\nmeloxicam total 17181; 2002: 4; 2003: 169; 2004: 688; 2005: 899; 2006: 867; 2007: 826; 2008: 859; 2009: 1523; 2010: 1218; 2011: 946; 2012: 1778; 2013: 729; 2014: 547; 2015: 498; 2016: 566; 2017: 550; 2018: 483; 2019: 571; 2020: 728; 2021: 432; 2022: 434; 2023: 435; 2024: 656; 2025: 668; 2026: 107\nmilbemycin total 236728; 1990: 27; 1991: 68; 1992: 38; 1993: 29; 1994: 16; 1995: 27; 1996: 64; 1997: 58; 1998: 202; 1999: 766; 2000: 738; 2001: 561; 2002: 389; 2003: 550; 2004: 1547; 2005: 2038; 2006: 2806; 2007: 3712; 2008: 4266; 2009: 4645; 2010: 4189; 2011: 11666; 2012: 25521; 2013: 26872; 2014: 22357; 2015: 19176; 2016: 16156; 2017: 15309; 2018: 14674; 2019: 13656; 2020: 12040; 2021: 8727; 2022: 6499; 2023: 5674; 2024: 5859; 2025: 4938; 2026: 868\nmilbemycin oxime total 193924; 2002: 1; 2005: 4; 2006: 3; 2007: 3; 2008: 1; 2009: 7; 2010: 8; 2011: 4222; 2012: 24698; 2013: 26819; 2014: 22312; 2015: 19138; 2016: 16145; 2017: 15300; 2018: 14669; 2019: 13634; 2020: 11036; 2021: 7197; 2022: 5169; 2023: 4485; 2024: 4628; 2025: 3773; 2026: 672\nmoxidectin total 96699; 1997: 136; 1998: 820; 1999: 464; 2000: 423; 2001: 1040; 2002: 2495; 2003: 2235; 2004: 2588; 2005: 488; 2006: 223; 2007: 639; 2008: 793; 2009: 1330; 2010: 1800; 2011: 2234; 2012: 2892; 2013: 3095; 2014: 3437; 2015: 3198; 2016: 3211; 2017: 4086; 2018: 4309; 2019: 6049; 2020: 7433; 2021: 6528; 2022: 5488; 2023: 5975; 2024: 8893; 2025: 11740; 2026: 2657\nnitenpyram total 21322; 2001: 40; 2002: 38; 2003: 113; 2004: 285; 2005: 334; 2006: 303; 2007: 351; 2008: 376; 2009: 345; 2010: 315; 2011: 467; 2012: 597; 2013: 583; 2014: 1029; 2015: 1359; 2016: 2031; 2017: 2178; 2018: 1512; 2019: 1383; 2020: 1184; 2021: 1095; 2022: 1180; 2023: 1417; 2024: 1716; 2025: 1008; 2026: 83\noclacitinib total 29980; 2013: 60; 2014: 1813; 2015: 2729; 2016: 3995; 2017: 4047; 2018: 2524; 2019: 1916; 2020: 1899; 2021: 1461; 2022: 1461; 2023: 1636; 2024: 2784; 2025: 3060; 2026: 595\npraziquantel total 79252; 1987: 3; 1988: 7; 1989: 3; 1990: 5; 1991: 5; 1992: 10; 1993: 19; 1994: 18; 1995: 26; 1996: 56; 1997: 54; 1998: 63; 1999: 52; 2000: 44; 2001: 59; 2002: 88; 2003: 256; 2004: 350; 2005: 321; 2006: 352; 2007: 702; 2008: 1033; 2009: 1253; 2010: 1573; 2011: 1646; 2012: 2051; 2013: 2900; 2014: 3444; 2015: 3324; 2016: 3906; 2017: 5718; 2018: 6679; 2019: 7505; 2020: 6851; 2021: 5526; 2022: 4417; 2023: 4999; 2024: 5992; 2025: 6563; 2026: 1379\npyrantel total 251640; 1987: 3; 1988: 2; 1989: 1; 1990: 4; 1991: 11; 1992: 6; 1993: 8; 1994: 23; 1995: 40; 1996: 139; 1997: 132; 1998: 230; 1999: 227; 2000: 290; 2001: 308; 2002: 482; 2003: 732; 2004: 1979; 2005: 2758; 2006: 3835; 2007: 5628; 2008: 6636; 2009: 7935; 2010: 7985; 2011: 7417; 2012: 9301; 2013: 11222; 2014: 10963; 2015: 11797; 2016: 11731; 2017: 12378; 2018: 11915; 2019: 12174; 2020: 12546; 2021: 16745; 2022: 17831; 2023: 18480; 2024: 20770; 2025: 22501; 2026: 4475\nsarolaner total 79692; 2016: 460; 2017: 2130; 2018: 3016; 2019: 4124; 2020: 5818; 2021: 9867; 2022: 12010; 2023: 13033; 2024: 13421; 2025: 13232; 2026: 2581\nselamectin total 71505; 1999: 179; 2000: 5736; 2001: 4772; 2002: 3514; 2003: 1488; 2004: 2060; 2005: 2203; 2006: 2403; 2007: 2803; 2008: 2778; 2009: 2877; 2010: 2804; 2011: 2500; 2012: 2716; 2013: 2737; 2014: 2543; 2015: 2555; 2016: 2696; 2017: 2573; 2018: 2247; 2019: 2841; 2020: 2687; 2021: 2538; 2022: 2133; 2023: 2264; 2024: 2265; 2025: 2207; 2026: 386\nsirolimus total 40; 2022: 1; 2024: 1; 2025: 26; 2026: 12\nspinosad total 212330; 2007: 56; 2008: 3345; 2009: 3602; 2010: 9003; 2011: 17254; 2012: 32582; 2013: 35885; 2014: 27309; 2015: 22506; 2016: 16421; 2017: 12759; 2018: 9554; 2019: 7435; 2020: 5665; 2021: 3378; 2022: 2083; 2023: 1433; 2024: 1034; 2025: 859; 2026: 167\n\nSource JSON: `pdf-raw/ade/ade_timeseries_20260730.json` (openFDA animalandveterinary/event.json, pulled 2026-07-30; per-drug `total` = sum of annual buckets; annual buckets from `count=original_receive_date` aggregated to year).\n","sources":["US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database) — FDA ADE annual report trends by active ingredient (retrieved 2026-07-30)"],"source":{"authority":"US FDA Center for Veterinary Medicine (openFDA animal & veterinary event database)","title":"FDA ADE annual report trends by active ingredient","url":"https://api.fda.gov/animalandveterinary/event.json","retrieved":"2026-07-30","ref":"","doc_type":"open dataset (JSON API)","source_document":"FDA CVM Animal & Veterinary Event Reports (openFDA animalandveterinary/event.json)","verification_file":"pdf-raw/ade/ade_timeseries_20260730.json"},"source_document":"FDA CVM Animal & Veterinary Event Reports (openFDA animalandveterinary/event.json)","source_file":"pdf-raw/ade/ade_timeseries_20260730.json","tokens_estimated":1200,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}