{"topic_id":"FDA_GRAS_notification_list_2026","category":"fda","context":"The FDA GRAS Notification program (21 CFR 170.30, subpart E) replaces the older SCOGS GRAS affirmation process. As of 2026, GRN 1-1000+ have been published. Pet food-relevant GRNs in the last 5 years: GRN 925 (2024) — coconut oil as GRAS for use in dog/cat foods up to 15% of diet; GRN 887 (2023) — yeast extract (Saccharomyces cerevisiae) derived nucleotides as GRAS for pet food at 0.1-0.5% DM; GRN 851 (2022) — insect meal (black soldier fly larvae, Hermetia illucens) as GRAS at 5-25% of dog/cat diets; GRN 798 (2021) — marine algae oil (Schizochytrium sp.) as source of DHA at 0.5-2% DM. Notable denials: GRN 765 (2021) — hemp-derived CBD was NOT affirmed GRAS (any amount), and CBD-containing pet food products remain classified as unapproved animal drugs requiring NADA.\n","sources":["generated from .md only"],"tokens_estimated":170,"generated_at":"2026-07-16","tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}