{"topic_id":"EFSA_OpenFoodTox_3_dataset_overview","category":"efsa","context":"---\ntopic_id: EFSA_OpenFoodTox_3_dataset_overview\ncategory: efsa\ntitle: EFSA OpenFoodTox 3.0 dataset overview — 7880 substances, 11613 dossiers, 19748 toxicological reference values (2003-2025)\nlang: en\nsource: OFT3.0_export_repository.xlsx\ndate_parsed: 2026-07-20\ntokens_estimated: 540\n---\n\nEFSA OpenFoodTox 3.0 (Zenodo record 19388272, DOI 10.5281/zenodo.19388272,\nreleased 2026-04-30, CC-BY 4.0) provides structured hazard data for\nsubstances assessed across EFSA's scientific remit (food additives,\nflavourings, pesticides, contaminants, food contact materials, feed\nadditives, and nutrients). The dataset is built on the IUCLID 6\nplatform, aligned with OECD Harmonised Templates (OHTs).\n\n## Top-level dimensions\n\n| Sheet | Rows | Description |\n|-------|-----:|-------------|\n| DOSSIER | 11613 | Scientific assessments (one row per dossier, typically one per EFSA opinion or revision) |\n| SUB | 7880 | Distinct substances (chemical entities) assessed in OFT |\n| REF_SUB | 7891 | Reference substance metadata (CAS, EC, IUPAC names) |\n| FLEX_SUM.ToxRefValues | 19748 | Toxicological reference values (ADIs, TDIs, ARfDs, etc.) |\n| END_SUM | 23567 | Study-level summary records |\n| LIT | 3186 | Literature references |\n| FLEX_REC | 4579 | Flexible records (study-level flexible fields) |\n| END_STUDY_REC.HumanHealth | 38809 | Human health study records |\n| END_STUDY_REC.AnimalHealth | 383 | Animal health study records (including pet species) |\n| END_STUDY_REC.TerrestEcotox | 5451 | Terrestrial ecotoxicology records |\n| END_STUDY_REC.AquaticEcotox | 3498 | Aquatic ecotoxicology records |\n| END_STUDY_REC.PhysChemProps | 25148 | Physicochemical property records |\n\n## Substance composition (SUB sheet)\n\n| Composition type | Count | Share |\n|------------------|------:|------:|\n| mono-constituent substance | 4244 | 53.9% |\n| multi-constituent substance | 956 | 12.1% |\n| polymer | 101 | 1.3% |\n| microorganism or toxin produced by a microorganism | 139 | 1.8% |\n| (no composition type recorded) | 2438 | 30.9% |\n| other | 2 | 0.03% |\n| **Total substances** | **7880** | **100%** |\n\n## Substance origin (SUB sheet)\n\n| Origin | Count | Share |\n|--------|------:|------:|\n| organic | 6184 | 78.5% |\n| inorganic | 276 | 3.5% |\n| organometallic | 92 | 1.2% |\n| other | 78 | 1.0% |\n| (no origin recorded) | 1250 | 15.9% |\n\n## Dossier ExpertGroup distribution\n\n| Expert Group | Dossiers | Share |\n|--------------|---------:|------:|\n| EFSA CEF (Food Additives) | 4335 | 37.3% |\n| EFSA AFC (Additives, Food Contact, Flavourings — predecessor to CEF, 2003-2008) | 2027 | 17.5% |\n| EFSA (multi-panel or unassigned) | 1999 | 17.2% |\n| **EFSA FEEDAP (Feed Additives)** | **1331** | **11.5%** |\n| EFSA ANS (Additives & Nutrient Sources) | 557 | 4.8% |\n| EFSA CONTAM (Contaminants) | 538 | 4.6% |\n| EFSA FAF (Food Additives & Flavourings, current name of CEF since 2022) | 324 | 2.8% |\n| EFSA NDA (Dietetic Products, Nutrition & Allergies) | 238 | 2.1% |\n| EFSA PPR (Plant Protection Products) | 198 | 1.7% |\n| SCF (Scientific Committee on Food — EFSA predecessor, pre-2003) | 16 | 0.1% |\n| EFSA CEP (Contact Materials, Enzymes & Processing Aids) | 19 | 0.2% |\n| **Total dossiers** | **11613** | **100%** |\n\n## Dossier year distribution (DateOfEvaluation)\n\n| Year | Dossiers | Notes |\n|------|---------:|-------|\n| 2000-2002 | 12 | SCF + early EFSA-Q pre-assignments |\n| 2003 | 21 | EFSA operational start |\n| 2004 | 257 | First EFSA operational year |\n| 2005 | 353 | |\n| 2006 | 267 | |\n| 2007 | 1000 | Bulk adoption of backlog opinions |\n| 2008 | 908 | |\n| 2009 | 1196 | Peak year |\n| 2010 | 750 | |\n| 2011 | 1152 | |\n| 2012 | 892 | |\n| 2013 | 712 | |\n| 2014 | 649 | |\n| 2015 | 560 | |\n| 2016 | 540 | |\n| 2017 | 383 | Transition year — FAF reorganization |\n| 2018 | 540 | |\n| 2019 | 370 | |\n| 2020 | 228 | COVID-impacted output |\n| 2021 | 247 | |\n| 2022 | 208 | |\n| 2023 | 172 | |\n| 2024 | 174 | |\n| 2025 | 19 | Partial year through 2026-04-30 |\n\nPeak production years: 2007-2011 with an average of 1001 dossiers\nper year. The 2020 dip reflects COVID-19 impact on EFSA working\nprocedures. 2025 shows partial-year data only because the dataset\ncutoff was 2026-04-30.\n\n## Toxicological reference values\n\n`FLEX_SUM.ToxRefValues` (19748 rows × 80 cols) is the dataset's core\noutput for downstream risk assessment. Each row represents a\nreference value (ADI, TDI, ARfD, AOEL, etc.) for a substance and\nspecies/endpoint combination. The 19748 reference values cover 7880\nsubstances across human health, animal health, and ecotoxicology\nendpoints, implying an average of 2.5 reference values per substance.\n\nSource: `toxicology/efsa/OFT3.0_export_repository.xlsx`, all 18\nsheets, 22,595,502 bytes total (Zenodo metadata verified\nsize=22595502). Published 2026-04-30 under CC-BY 4.0.","sources":[],"tokens_estimated":540,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}