{"topic_id":"EFSA_OpenFoodTox_3_FEEDAP_chemistry_breakdown","category":"efsa","context":"---\ntopic_id: EFSA_OpenFoodTox_3_FEEDAP_chemistry_breakdown\ncategory: efsa\ntitle: EFSA OpenFoodTox 3.0 FEEDAP dossier chemistry breakdown — 882 organic mono-constituent, 11 organic polymer (pet food additives), 98 microorganism\nlang: en\nsource: OFT3.0_export_repository.xlsx\ndate_parsed: 2026-07-20\ntokens_estimated: 510\n---\n\nCross-tabulation of EFSA FEEDAP dossier-level metadata\n(1331 dossiers) against the chemical composition × origin\nclassification of the associated substance (via DOSSIER_DOCS\ntype=SUBSTANCE join). The 1331 FEEDAP dossiers all link to a\nsingle substance each (1-to-1 strict join).\n\n## FEEDAP dossier chemistry breakdown (Composition × Origin)\n\n| Composition | Origin | Count | Share |\n|-------------|--------|------:|------:|\n| mono-constituent substance | organic | 882 | 66.3% |\n| multi-constituent substance | (no origin) | 168 | 12.6% |\n| microorganism or toxin produced by a microorganism | (no origin) | 98 | 7.4% |\n| mono-constituent substance | inorganic | 62 | 4.7% |\n| multi-constituent substance | organic | 38 | 2.9% |\n| mono-constituent substance | organometallic | 24 | 1.8% |\n| multi-constituent substance | organometallic | 14 | 1.1% |\n| **polymer** | **organic** | **11** | **0.8%** |\n| multi-constituent substance | `other:` | 10 | 0.8% |\n| (no composition) | (no origin) | 8 | 0.6% |\n| mono-constituent substance | (no origin) | 6 | 0.5% |\n| polymer | (no origin) | 3 | 0.2% |\n| multi-constituent substance | inorganic | 3 | 0.2% |\n| microorganism or toxin | `other:` | 2 | 0.2% |\n| microorganism or toxin | organic | 1 | 0.1% |\n| mono-constituent substance | `other:` | 1 | 0.1% |\n| **Total FEEDAP dossiers** | | **1331** | **100%** |\n\n## Composition summary for FEEDAP\n\n| Composition type | Count | Share |\n|------------------|------:|------:|\n| mono-constituent substance | 975 | 73.3% |\n| multi-constituent substance | 233 | 17.5% |\n| microorganism or toxin produced by a microorganism | 101 | 7.6% |\n| polymer | 14 | 1.1% |\n| (no composition recorded) | 8 | 0.6% |\n\n## Origin summary for FEEDAP\n\n| Origin type | Count | Share |\n|-------------|------:|------:|\n| organic | 933 | 70.1% |\n| inorganic | 65 | 4.9% |\n| organometallic | 38 | 2.9% |\n| `other:` | 13 | 1.0% |\n| (no origin recorded) | 282 | 21.2% |\n\n## Pet food-relevant chemistry subset\n\nFEEDAP dossiers where the associated substance is in pet-food-\nrelevant chemistry categories:\n\n| Category | Subset | Count |\n|----------|--------|------:|\n| Hydrocolloids / gelling agents (polymer + organic) | polymer × organic | 11 |\n| Hydrocolloids (polymer, origin undefined) | polymer × (no origin) | 3 |\n| Mineral salts / inorganic preservatives | mono-constituent × inorganic | 62 |\n| Organic acids / palatants | mono-constituent × organic | 882 |\n| Flavour mixtures | multi-constituent × organic | 38 |\n| Probiotics / direct-fed microbials | microorganism × (no origin) | 98 |\n\n**Total pet-food-relevant FEEDAP dossiers: ~1194 (89.7%)** —\nnearly all FEEDAP dossiers touch at least one pet-food-relevant\nchemistry category. This reflects how broadly Reg 1831/2003 feed\nadditives apply to all animal species, including pets.\n\n## 11 polymer × organic dossiers (deep dive target)\n\nOf the 14 polymer dossiers in FEEDAP, 11 are organic polymers —\nthe chemistry class that includes the 3 explicit \"for pets\"\nadditive dossiers identified earlier:\n- carrageenan (2022-03-23, doi:10.2903/j.efsa.2022.7285)\n- agar (2022-03-23, doi:10.2903/j.efsa.2022.7284)\n- sodium/potassium alginate (2017-07-05, doi:10.2903/j.efsa.2017.4945)\n\nThe remaining 8 dossiers in this subset include other hydrocolloid\npolymers (xanthan gum, pectin, carboxymethyl cellulose) and\nsynthetic polymers used as feed additive carriers.\n\n## Microorganism subset (101 dossiers)\n\n101 FEEDAP dossiers cover microorganisms or their toxins — the\nlargest non-organic chemistry class in FEEDAP. This category\nincludes:\n- **Probiotics** (Lactobacillus, Bifidobacterium, Enterococcus\n  strains) used as zootechnical additives (gut flora stabilizers)\n- **Silage inoculants** (Lactobacillus plantarum, etc.) used as\n  technological additives\n- **Yeast derivatives** (Saccharomyces cerevisiae products) used\n  as nutritional/sensory additives\n\nThese dossiers are often multi-strain formulations with broad\nspecies applicability including pets.\n\n## Data quality observations\n\n1. **21.2% of FEEDAP substances have no Origin recorded (282)** —\n   gap in IUCLID population for organic chemicals of natural\n   origin (botanical extracts, fermentation products).\n2. **Multi-constituent × (no origin) is the second-largest cell\n   (168)** — these are likely complex mixtures (essential oils,\n   plant extracts, fermentation products) where Origin is hard to\n   assign to a single chemical class.\n3. **Polymer × organic at 11 dossiers is a tight subset** —\n   almost certainly the \"gelling agents and hydrocolloids\" sub-\n   category used heavily in wet pet food formulation.\n\n## Pet food relevance summary\n\nThe 11 organic polymer dossiers, 98 microorganism dossiers, 62\ninorganic mineral dossiers, and 38 multi-constituent organic\ndossiers are the FEEDAP subsets most directly applicable to pet\nfood formulation under EU Reg 1831/2003. The remaining\n~1120 dossiers (mostly mono-constituent organic) cover generic\nfeed additives (vitamins, amino acids, preservatives, antioxidants)\nthat apply to pet food at the same usage rates as livestock feed.\n\nSource: `toxicology/efsa/OFT3.0_export_repository.xlsx`,\nsheets `DOSSIER` (1331 FEEDAP rows), `DOSSIER_DOCS` (SUBSTANCE\ntype join keys), `SUB` (Composition + Origin).\nJoin: `DOSSIER.Document UUID` → `DOSSIER_DOCS.DOSSIER UUID`\n(filter type=SUBSTANCE) → `DOSSIER_DOCS.DOCUMENT UUID` =\n`SUB.Document UUID`.","sources":[],"tokens_estimated":510,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}