{"topic_id":"EFSA_FEEDAP_lvaline_safety","category":"efsa","context":"---\ntopic_id: EFSA_FEEDAP_lvaline_safety\ncategory: efsa\ntitle: \"EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782)\"\nlang: en\nsource: \"EFSA FEEDAP scientific opinion, EFSA Journal 2025;23(12):e9782 (DOI 10.2903/j.efsa.2025.9782)\"\nsource_file: pdf-raw/efsa_l/PMC12712539.xml\nsource_type: journal_article\ndate_parsed: 2026-08-06\ntokens_estimated: 470\nverified: true\nverification:\n  method: paraphrase\n  claims: 6\n  passed: 6\n  date: 2026-08-06\nsource_document: \"EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782)\"\ncitation:\n  authority: \"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)\"\n  title: \"EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782)\"\n  url: \"https://doi.org/10.2903/j.efsa.2025.9782\"\n  retrieved: \"2026-08-06\"\n  ref: \"EFSA Journal 2025;23(12):e9782\"\n  doc_type: \"EFSA scientific opinion (Europe PMC OA full-text XML)\"\n  needs_review: false\nauthority_tier: T1\nauthority_tier_basis: \"T1:eu-body\"\nauthority_tier_date: 2026-08-06\n---\n# EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species\n\nSource: EFSA FEEDAP scientific opinion, EFSA Journal 2025;23(12):e9782 (DOI 10.2903/j.efsa.2025.9782), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.\n\n## Editorial context (read this before using the data point)\n\nThis is the **EFSA FEEDAP** jurisdiction on the amino-acid feed additive **C. glutamicum KCCM 80366** — one of four amino-acid safety opinions in this batch. Read with the `efsa` nutrient endpoints and AAFCO/FEDIAF amino-acid provisions.\n\n## Key findings (paraphrase; numbers and proper nouns verbatim from source)\n\n- L-valine is produced using the **non-genetically modified *C. glutamicum* KCCM 80366**; **viable cells were not detected** and the strain **does not harbour any gene of concern**.\n- Its use in animal nutrition is considered **safe for all animal species, the consumers and for the environment**.\n- For user safety it is **not irritant to skin** but **is considered a skin and respiratory sensitiser** (no conclusion on eye irritancy); inhalation and dermal exposure are a risk.\n- It is an **effective source of the essential amino acid L-valine for all animal species**; to match non-ruminant efficacy in ruminants it should be protected from ruminal degradation.\n\n## Pet-food relevance\n\nL-valine is an essential amino acid in cats and dogs. The unqualified 'safe for all animal species, consumers and environment' conclusion (non-GM strain, no gene of concern) is the headline; the user-sensitiser warning is the practical handling caveat. The ~1.1% unidentified fraction is the stated residual uncertainty.\n\n## Scope note / honest gap\n\nParaphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full strain-characterisation and toxicity statistics are not reproduced.\n","sources":["OFT3 — EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782) (retrieved 2026-08-06)"],"source":{"authority":"OFT3","title":"EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782)","url":"https://doi.org/10.2903/j.efsa.2025.9782","retrieved":"2026-08-06","ref":"","doc_type":"official PDF","source_document":"EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782)","verification_file":"pdf-raw/efsa_l/PMC12712539.xml"},"source_document":"EFSA FEEDAP — L-valine (C. glutamicum KCCM 80366, non-GM) for all animal species: safe for species/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2025;23(12):e9782)","source_file":"pdf-raw/efsa_l/PMC12712539.xml","trust":{"authority_tier":"T1","fidelity":"paraphrase","license":null,"display_grade":"C"},"tokens_estimated":420,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}