{"topic_id":"EFSA_FEEDAP_lmethionine_safety","category":"efsa","context":"---\ntopic_id: EFSA_FEEDAP_lmethionine_safety\ncategory: efsa\ntitle: \"EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247)\"\nlang: en\nsource: \"EFSA FEEDAP scientific opinion, EFSA Journal 2022;20(4):e07247 (DOI 10.2903/j.efsa.2022.7247)\"\nsource_file: pdf-raw/efsa_l/methionine_feed.xml\nsource_type: journal_article\ndate_parsed: 2026-08-06\ntokens_estimated: 450\nverified: true\nverification:\n  method: paraphrase\n  claims: 7\n  passed: 7\n  date: 2026-08-06\nsource_document: \"EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247)\"\ncitation:\n  authority: \"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)\"\n  title: \"EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247)\"\n  url: \"https://doi.org/10.2903/j.efsa.2022.7247\"\n  retrieved: \"2026-08-06\"\n  ref: \"EFSA Journal 2022;20(4):e07247\"\n  doc_type: \"EFSA scientific opinion (Europe PMC OA full-text XML)\"\n  needs_review: false\nauthority_tier: T1\nauthority_tier_basis: \"T1:eu-body\"\nauthority_tier_date: 2026-08-06\n---\n# EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species\n\nSource: EFSA FEEDAP scientific opinion, EFSA Journal 2022;20(4):e07247 (DOI 10.2903/j.efsa.2022.7247), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.\n\n## Editorial context (read this before using the data point)\n\nThis is the **EFSA FEEDAP** jurisdiction on the nutrient/additive **L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246)** — one of four nutrient-safety opinions in this batch (Task L). Read with the `efsa` nutrient endpoints and AAFCO/FEDIAF provisions for the same nutrient.\n\n## Key findings (paraphrase; numbers and proper nouns verbatim from source)\n\n- Production strains are **C. glutamicum KCCM 80245** and **E. coli KCCM 80246**; **viable cells and recombinant DNA were not detected** in the products, so the strains raise no safety concern.\n- Used to **compensate for L-methionine deficiency** in feed, the additive is **safe for the target species** and **safe for consumers and the environment**.\n- The Panel has **concerns on amino acids in drinking water** (hygiene; imbalance risk when given simultaneously via feed).\n- **User safety**: not irritant to skin/eyes, not a dermal sensitiser, no inhalation toxicity — **but L-methionine ≥ 90% is a user risk** due to respiratory endotoxin exposure.\n- It is an **efficacious source of the essential amino acid L-methionine for non-ruminants**; ruminants need protection against ruminal degradation.\n\n## Pet-food relevance\n\nL-methionine is an essential amino acid and typically the first-limiting one in cat and dog diets. The positive safety conclusion plus the drinking-water caveat and the ≥90% user-risk warning are the usable formulator/handling takeaways.\n\n## Scope note / honest gap\n\nParaphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full characterisation and tolerance statistics are not reproduced.\n","sources":["OFT3 — EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247) (retrieved 2026-08-06)"],"source":{"authority":"OFT3","title":"EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247)","url":"https://doi.org/10.2903/j.efsa.2022.7247","retrieved":"2026-08-06","ref":"","doc_type":"official PDF","source_document":"EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247)","verification_file":"pdf-raw/efsa_l/methionine_feed.xml"},"source_document":"EFSA FEEDAP — L-methionine (C. glutamicum KCCM 80245 + E. coli KCCM 80246) for all animal species: safe; drinking-water concerns; ≥90% a user risk (EFSA Journal 2022;20(4):e07247)","source_file":"pdf-raw/efsa_l/methionine_feed.xml","trust":{"authority_tier":"T1","fidelity":"paraphrase","license":null,"display_grade":"C"},"tokens_estimated":460,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}