{"topic_id":"EFSA_FEEDAP_llysine_sulfate_safety","category":"efsa","context":"---\ntopic_id: EFSA_FEEDAP_llysine_sulfate_safety\ncategory: efsa\ntitle: \"EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3))\"\nlang: en\nsource: \"EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(3) (DOI 10.2903/j.efsa.2026.9922)\"\nsource_file: pdf-raw/efsa_l/PMC12954135.xml\nsource_type: journal_article\ndate_parsed: 2026-08-06\ntokens_estimated: 470\nverified: true\nverification:\n  method: paraphrase\n  claims: 6\n  passed: 6\n  date: 2026-08-06\nsource_document: \"EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3))\"\ncitation:\n  authority: \"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)\"\n  title: \"EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3))\"\n  url: \"https://doi.org/10.2903/j.efsa.2026.9922\"\n  retrieved: \"2026-08-06\"\n  ref: \"EFSA Journal 2026;24(3)\"\n  doc_type: \"EFSA scientific opinion (Europe PMC OA full-text XML)\"\n  needs_review: false\nauthority_tier: T1\nauthority_tier_basis: \"T1:eu-body\"\nauthority_tier_date: 2026-08-06\n---\n# EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species\n\nSource: EFSA FEEDAP scientific opinion, EFSA Journal 2026;24(3) (DOI 10.2903/j.efsa.2026.9922), retrieved 2026-08-06 via Europe PMC OA full-text XML. Paraphrase of an EFSA opinion that the source XML tags CC-BY-ND; per project COPYRIGHT_POLICY only facts/numbers/proper-nouns are quoted verbatim, sentences rewritten.\n\n## Editorial context (read this before using the data point)\n\nThis is the **EFSA FEEDAP** jurisdiction on the amino-acid feed additive **C. glutamicum KCCM 80368** — one of four amino-acid safety opinions in this batch. Read with the `efsa` nutrient endpoints and AAFCO/FEDIAF amino-acid provisions.\n\n## Key findings (paraphrase; numbers and proper nouns verbatim from source)\n\n- L-lysine sulfate is produced using the **genetically modified strain *C. glutamicum* KCCM 80368**; the additive was **characterised up to 93.2%** and the conclusions apply only to that manufacturing process.\n- **Viable cells were not detected**; DNA from the strain is present but **not considered of concern**, so the GM strain raises no safety concern.\n- Its use in animal nutrition is considered **safe for the target animals, the consumer and the environment**.\n- For user safety it is **not irritant to the skin** (no conclusion on eye irritation) but **should be considered a respiratory and skin sensitiser**; inhalation and dermal exposure are a risk.\n- It is an **effective source of the essential amino acid L-lysine for all animal species**; to match non-ruminant efficacy in ruminants it should be protected from ruminal degradation.\n\n## Pet-food relevance\n\nL-lysine is an essential amino acid in cats and dogs. The positive overall safety conclusion (target animals, consumer, environment) and the user-sensitiser warning are the directly usable data points; the ~7% unidentified fraction (fermentation residues) is the stated residual uncertainty.\n\n## Scope note / honest gap\n\nParaphrase of an EFSA opinion; source XML licence tag was CC-BY-ND, so this topic quotes only data points verbatim and rewrites prose. Full sub-chronic and genotoxicity study details are not reproduced.\n","sources":["OFT3 — EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3)) (retrieved 2026-08-06)"],"source":{"authority":"OFT3","title":"EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3))","url":"https://doi.org/10.2903/j.efsa.2026.9922","retrieved":"2026-08-06","ref":"","doc_type":"official PDF","source_document":"EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3))","verification_file":"pdf-raw/efsa_l/PMC12954135.xml"},"source_document":"EFSA FEEDAP — L-lysine sulfate (C. glutamicum KCCM 80368, GM) for all animal species: safe for target animals/consumer/environment; skin & respiratory sensitiser (EFSA Journal 2026;24(3))","source_file":"pdf-raw/efsa_l/PMC12954135.xml","trust":{"authority_tier":"T1","fidelity":"paraphrase","license":null,"display_grade":"C"},"tokens_estimated":440,"generated_at":null,"tip":"Use /api/v1/topics to discover more topics. /api/v1/nutrient for precise single-point queries. /api/v1/cross_compare for 2-3 standard comparisons."}